Western Australian Institute for Medical Research (WAIMR)


http://www.waimr.uwa.edu.au

Dr Fang-Xu Jiang

Fang-Xu Jiang

Phone: +61 8 9224 0388
Email: fangxu.jiang@waimr.uwa.edu.au

Dr Fang-Xu Jiang has over 20 years experience in medical research both in Australia and overseas. In the early 1990s, Dr Jiang and his colleagues pioneered the establishment of male germ cell transplantation in rats, a novel technique for functional assay of male stem germ cells. For this contribution Dr Jiang was awarded the European Academy of Andrology Prize 1996 and Hamilton Thorne Research Prize 1996 (USA).

Dr Jiang switched his career path eleven years ago and committed to find a cure for type 1 diabetes, a disease has doubled in incidence in last 20 years in Australia. His research interest focuses mainly on proliferation, differentiation, self-renewal and regeneration of pancreatic insulin-secreting β cells, including the molecular mechanisms of these biological processes. The ultimate aim is to generate unlimited number of β cells in vitro or stimulate patient's own progenitor/stem cells to become β cells in vivo to cure this disease.

Qualifications

1982BMed - West China University of Medical Sciences, Chengdu, Sichuan, China
1985MMed - Hunan Medical University, Changsha, Hunan, China
1992MRepSc - Reproductive Biology, Monash University, Australia
1996PhD - Reproductive Biology, University of Melbourne, Australia
Thesis Title: "Male germ cell transplantation"

Research Interests

  • Insulin-secreting cell development and regeneration.
  • Pancreatic progenitor/stem cell biology.
  • Gene expression and regulation.
  • Development of high throughput cell-based assay.

Scientific Involvement

  • Australian-Chinese Biomedical Science Association - Chair, Academic Committee.

Top 10 Publications

  1. Jiang F-X, Short RV. 1995. Male germ cell transplantation in rats: apparent synchronisation of spermatogenesis between host and donor seminiferous epithelia. Int. J. Androl. 18:43-47.
  2. Jiang F-X. 1998. Behavior of spermatogonia following recovery from busulfan treatment in the rat. Anat Embryol 198:53-61.
  3. Jiang F-X, Short RV. 1998. Different fate of primordial germ cells and gonocytes following transplantation. APMIS 106:58-63.
  4. Jiang F-X, Cram DC, DeAizpurua H, Harrison LC. 1999. Laminin-1 promotes differentiation of fetal mouse pancreatic β cells. Diabetes 48:722-30.
  5. Jiang F-X, Georges-Labouesse E, Harrison LC. 2001. Regulation of laminin-1-induced pancreatic β-cell development by α6 integrins and α-dystroglycan. Mol Med 7:107-14.
  6. Jiang F-X, Stanley E, Gonez J, Harrison LC. 2002. Bone morphogenetic proteins promote development of fetal pancreas epithelial colonies containing insulin-positive cells. J Cell Sci 115:753-60.
  7. Jiang F-X, Naselli G, Harrison LC. 2002. Distinct distribution of laminin and its integrin receptors in the pancreas. J Histochem Cytochm 50:1625-32.
  8. Jiang F-X, Harrison LC. 2003. Difference in generating mouse pancreatic epithelial cell colonies in vitro. Pancreas 27:204-6.
  9. Jiang F-X, Harrison LC. 2005. Laminin-1 and epidermal growth factor family members co-stimulate fetal pancreas cell proliferation and colony formation. Differentiation 73:45-49.
  10. Jiang F-X, Harrison LC. 2005. Convergence of bone morphogenetic protein and laminin-1 signaling pathways promotes proliferation and colony formation by fetal mouse pancreatic cells. Exp Cell Res 308:114-22.