Western Australian Institute for Medical Research (WAIMR)


http://www.waimr.uwa.edu.au

Dr Aron Chakera

Aron Chakera

Dr Aron Chakera is a renal physician at Sir Charles Gairdner Hospital, with a particular interest in transplantation and autoimmune diseases. He is also the clinical lead for peritoneal dialysis. Prior to returning to Western Australia in 2012, he was the Clinical Lecturer in Renal Medicine at the University of Oxford, where he worked with Professor Richard Cornall studying lymphocyte subsets and responses to recall antigens in patients receiving immunosuppression.

Qualifications

1999MBBS(Hon) - The University of Western Australia, Perth, Australia
2004MRCP(UK)
2005DPhil - University of Oxford, United Kingdom
2008PGDipLATHE - University of Oxford, United Kingdom

Research Interests

  • Quantification of immune function, particularly under conditions of immunosuppression.
  • The role of follicular-helper T-cells (TFH) in autoimmunity.
  • Peritoneal mesothelial cell biology.
  • EPO-R dimerization.

Memberships/Fellowships

  • Australian and New Zealand Society of Nephrology.
  • Higher Education Academy.
  • American Society of Nephrology.
  • Royal College of Physicians.

Recent Publications

  1. Chakera A, Bennett S, Morteau O. Bowness P, Luqmani R, Cornall RJ. 2012. The phenotype of circulating follicular-helper T cells in patients with rheumatoid arthritis defines CD200 as a potential therapeutic target. Clinical and Developmental Immunology doi:10.1155/2012/948218.
  2. Koneitzny R, Fischer R, Ternette N, Chakera A, Wright C, Turney BW, Hughes D, Kessler B, Pugh CW. 2012. Proteomic characterization of BK virus subtypes in the urine from renal transplant subjects. Clinical Proteomics 9(1):4. [NCBI PubMed Entry]
  3. Chakera A, Dyar O-J, Hughes E, Bennett S, Hughes D, Roberts IR. 2011. Detection of polyomavirus BK reactivation following renal transplantation using an intensive decoy cell surveillance program is cost effective. Transplantation 92(9):1018-23. [NCBI PubMed Entry]
  4. Chakera A, Bennett S, Cornall RJ. 2011. A whole blood monokine-based reporter assay provides a sensitive and robust measurement of the antigen-specific T cell response. Journal of Translational Medicine 9:143. doi: 10.1186/1479-5876-9-143. [NCBI PubMed Entry]
  5. Chakera A, Bennett S, Lawrence S, Mason PD, O'Callaghan CA, Cornall RJ. 2011. Antigen-specific T-cell responses to BK polyomavirus identifies functional antiviral immunity and may help guide immunosuppression following renal transplantation. Clinical and Experimental Immunology 165(3):401-9. [NCBI PubMed Entry]
  6. Chakera A, Lucas A, Lucas M. 2011. Surrogate markers of infection: interrogation of the immune system. Biomarkers in Medicine 5(2):131-48. [NCBI PubMed Entry]
  7. Morteau O, Blundell S, Chakera A, Bennett S, Christou CM, Mason PD, Cornall RJ, O'Callaghan CA. 2010. Renal transplant immunosuppression impairs natural killer cell function in vitro and in vivo. PLoS One 5(10):e13294. [NCBI PubMed Entry]
  8. Watson AA, Christou CM, James JR, Fenton-May AE, Moncayo GE, Mistry AR, Davis SJ, Chakera A, O'Callaghan CA. 2009. The Platelet Receptor CLEC-2 is Active as a Dimer. Biochemistry 48(46):10988-96. [NCBI PubMed Entry]
  9. Chakera A, Seeber RM, John AE, Eidne KA, Greaves DR. 2008. The Duffy Antigen/Receptor for Chemokines (DARC) exists in an oligomeric form in living cells and functionally antagonises CCR5 signalling through hetero-oligomerization. Molecular Pharmacology 73(5):1262-70. [NCBI PubMed Entry]